WCY-8-67

WCY-8-67 is an orally active and selective USP5 inhibitor, with an IC50 value of 1.33 μM. WCY-8-67 induces apoptosis and suppresses JAK/STAT3 and PI3K/AKT signaling pathways in vitro. WCY-8-67 inhibits proliferation of AE-positive AML cells, induces G1 phase arrest and differentiation of AML cells. WCY-8-67 demonstrates potent anti-leukemic efficacy in mice. WCY-8-67 can be used for the study of acute myeloid leukemia .


Cat. No.: EX-A16555	Purity: >98%

	Chemical structure of WCY-8-67

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	490	In-stock
10mg	760	In-stock
25mg	1540	In-stock
50mg	2500	In-stock
100mg	3980	In-stock
250mg	7799	In-stock

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CAS No.	3052618-54-6
Purity	>98%
Formula	C25H32FN7
Mol Weight	449.5669

Reference:	[1].Ma L, et al. USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts. Sci Transl Med. 2025 Sep 24;17(817):eadt9100.
CoA	CoA of WCY-8-67

Smiles:	FC1=CC=C(C=2C=CC=CC12)N3CC=4N=C(N=C(C4C3)N(C)CCN(C)C)N5CCNCC5


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