WC-2

WC-2 is an ATP-competitive covalent WRN helicase inhibitor with IC50 values of 252 nM and 250 nM. WC-2 binds covalently to Cys727 of WRN helicase and maintains conformational complementarity with this protein. WC-2 induces p21 transcription as part of the DNA damage response, and selectively reduces the viability of MSI-H cancer cells. WC-2 can be used in the research of MSI-H tumors .


Cat. No.: EX-A17569	Purity:

	Chemical structure of WC-2

For research only, Do not use for Human!

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CAS No.	3112500-81-6
Formula	C21H21F3N2O4S
Mol Weight	454.463

CoA	CoA of WC-2

Smiles:	O=C(N[C@@H](C1CC1)/C=C(F)/S(C)(=O)=O)C2=CC=C(C(C)(F)F)C(OC3=CC=CC=C3)=N2


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