W23-1006

W23-1006 is a selective and covalent ALKBH5 inhibitor. W23-1006 binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. W23-1006 shows ~30- and 8-fold stronger inhibitory activity than that against FTO and ALKBH3, respectively. W23-1006 can be used for the study of triple-negative breast cancer (TNBC) .


Cat. No.: EX-A15968	Purity: >98%

	Chemical structure of W23-1006

For research only, Do not use for Human!

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1g	get quote

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CAS No.	3035498-92-8
Purity	>98%
Formula	C17H12BrN3O5
Mol Weight	418.198
Color	Brown to reddish brown
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yang X, et al. Discovery of a Novel Selective and Cell-Active N6-Methyladenosine RNA Demethylase ALKBH5 Inhibitor. J Med Chem. 2025 Feb 27;68(4):4133-4147.
CoA	CoA of W23-1006

Smiles:	O=C1NN(C(=O)C1=CC2=CC(Br)=CC(=C2)N(=O)=O)C3=CC=C(OC)C=C3


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