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Product Information:

W146 trifluoroacetate salt

W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

Cat. No.: EX-A6456A    Purity: >98%
Chemical
Chemical structure of W146 trifluoroacetate salt


For research only, Do not use for Human!

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SynonymsW146 trifluoroacetate
CAS No.909725-62-8
Purity>98%
FormulaC18H28F3N2O6P
Mol Weight456.3937
ColorWhite to off-white
StateSolid
SolubilityDMSO : 20 mg/mL Ethanol : < 1 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4℃, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9.

[2]. Jingjing Liu, et al. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1(4): 197–203.

[3]. Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.

CoACoA of W146 trifluoroacetate salt
Smiles:CCCCCCC1=CC(=CC=C1)NC(=O)[C@@H](CCP(=O)(O)O)N.C(=O)(C(F)(F)F)O

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