VX-803

VX-803 (M4344) is an ATP-competitive, orally active, and selective inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase with Ki of < 150 pM.


Cat. No.: EX-A4348	Purity: >98%

	Chemical structure of VX-803

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	585	In-stock
250mg	850	In-stock
500mg	1300	In-stock
1g	1850	In-stock
5g	5680	In-stock
10g	8276	In-stock

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Synonyms	Gartisertib
Synonyms 2	M4344
CAS No.	1613191-99-3
Purity	>98%
Formula	C25H29F2N9O3
Mol Weight	541.5531
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Frank T. Zenke, et al. Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy. Experimental and Molecular Therapeutics. [2]. Gorecki L, et al. Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy. Pharmacol Ther. 2020 Feb 26:107518.
CoA	CoA of VX-803

Smiles:	O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5CCN(C6COC6)CC5)=O)CC4)C(F)=CN=C3


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