VX-222

cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM.


Cat. No.: EX-A1758	Purity: >98%

	Chemical structure of VX-222

For research only, Do not use for Human!

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Synonyms	cis-VX-222
Synonyms 2	cis-Lomibuvir
CAS No.	1026785-59-0
Purity	>98%
Formula	C25H35NO4S
Mol Weight	445.615

Reference:	[1]. Yi G, Deval J, et al. Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir. Antimicrob Agents Chemother. 2012;56(2):830-837. [2]. Li P, Dorsch W, et al. Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates. ACS Med Chem Lett. 2017;8(2):251-255. Published 2017 Jan 31.
CoA	CoA of VX-222

Smiles:	CC1CCC(CC1)C(=O)N(C1CCC(O)CC1)C1=C(SC(=C1)C#CC(C)(C)C)C(O)=O


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