VVD-130037

VVD-130037 is an orally available covalent activator of KEAP (Kelch-like ECH-associated protein 1). VVD-130037 significantly inhibits tumor growth in advanced solid tumors by degrading NRF2 (nuclear factor-erythroid 2 p45-related factor 2).


Cat. No.: EX-A9765	Purity: >98%

	Chemical structure of VVD-130037

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	745	In-stock
250mg	1185	In-stock
1g	2485	In-stock
5g	get quote	In-stock

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Synonyms	BAY-3605349
CAS No.	3034880-93-5
Purity	>98%
Formula	C17H17ClN4O2
Mol Weight	344.795
Color	white to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chan Shan, et al. The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications. Int J Biol Sci. 2024 Nov 11;20(15):6181-6206. [2]. Gu X, et al. The Cancer Antioxidant Regulation System in Therapeutic Resistance. Antioxidants (Basel). 2024 Jun 27;13(7):778. [3]. Han B, et al. Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer. Cell Rep. 2024 Jul 23;43https://pubmed.ncbi.nlm.nih.gov/39003742/(7):114507.
CoA	CoA of VVD-130037

Smiles:	NC1=NC(C2=CC(Cl)=CC([C@@H]3COCCN3C(C=C)=O)=C2)=NC=C1


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