VU0360172 hydrochloride

VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice .


Cat. No.: EX-A9379	Purity: >98%

	Chemical structure of VU0360172 hydrochloride

For research only, Do not use for Human!

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Synonyms	VU-0360172 HCl
CAS No.	1309976-62-2
Purity	>98%
Formula	C18H16ClFN2O
Mol Weight	330.784
Color	White to off-white
State	Solid
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.
CoA	CoA of VU0360172 hydrochloride

Smiles:	Cl[H].FC1=CC(=CC=C1)C#CC1=CC=C(C=N1)C(=O)NC1CCC1


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