Voxtalisib

Voxtalisib (XL765) is a potent PI3K inhibitor, which has a similar activity toward class I PI3K (IC50s=39, 113, 9 and 43?nM for p110α, p110β, p110γ and p110δ, respectively), also inhibits DNA-PK (IC50=150?nM) and mTOR (IC50=157?nM). Voxtalisib (XL765) inhibits mTORC1 and mTORC2 with IC50s of 160 and 910 nM, respectively.


Cat. No.: EX-A4140	Purity: >98%

	Chemical structure of Voxtalisib

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	477	in_stock
500mg	720	in_stock
1g	1142	in_stock
2g	1774	in_stock
3g	2206	in_stock

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Synonyms	XL765
Synonyms 2	SAR245409
CAS No.	934493-76-2
Purity	>98%
Formula	C13H14N6O
Mol Weight	270.2899
Color	Light brown to brown
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Garcia-Echeverria C, et al. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene. 2008 Sep 18;27(41):5511-26. [2]. Yu P, et al. Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. Mol Cancer Ther. 2014 May;13(5):1078-91.
CoA	CoA of Voxtalisib

Smiles:	O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC


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