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Product Information:

Voxelotor

Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment.

Cat. No.: EX-A2980    Purity: >98%
Chemical
Chemical structure of Voxelotor


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg400In-stock
500mg650In-stock
1g1050In-stock
2g1700In-stock
5g3200In-stock
10g4500In-stock


SynonymsGBT 440
CAS No.1446321-46-5
Purity>98%
FormulaC19H19N3O3
Mol Weight337.3725
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years, , stored under nitrogen; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Oksenberg D, et al. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. Br J Haematol. 2016 Oct;175(1):141-53.

[2]. Metcalf B, Chuang C, Dufu K, et al. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. ACS Med Chem Lett. 2017;8(3):321-326.

CoACoA of Voxelotor
Smiles:CC(C)N1N=CC=C1C1=NC=CC=C1COC1=C(C=O)C(O)=CC=C1

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