Voreloxin hydrochloride

Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.


Cat. No.: EX-A847A	Purity: >98%

	Chemical structure of Voreloxin hydrochloride

For research only, Do not use for Human!

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CAS No.	175519-16-1
Purity	>98%
Formula	C18H20ClN5O4S
Mol Weight	437.9
Color	White to gray
State	Solid
Solubility	DMSO : 2 mg/mL H2O : 2 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture. In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hotinski AK, et al. Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia. Expert Opin Pharmacother. 2015 Jun;16(9):1395-402. [2]. Scatena CD, et al. Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. [3]. Walsby EJ, et al. The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine. Haematologica. 2011 Mar;96(3):393-9.
CoA	CoA of Voreloxin hydrochloride

Smiles:	O=C1C=2C(N(C=C1C(O)=O)C3=NC=CS3)=NC(=CC2)N4C[C@H](NC)[C@@H](OC)C4.Cl


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