Virapinib

Virapinib is a macropinocytosis inhibitor with antiviral activity. Virapinib exhibits broad-spectrum antiviral activity against SARS-CoV-2, monkeypox virus, tick-borne encephalitis virus, and Ebola pseudotyped vesicular stomatitis virus, and it enhances Dengue Virus infection. Virapinib blocks viral entry by inhibiting macropinocytosis, reduces syncytium formation in SARS-CoV-2-infected cells, and impairs cellular entry of SARS-CoV-2 variants. Virapinib upregulates the expression of genes related to sterol biosynthesis. Virapinib can be used in studies related to COVID-19, monkeypox, tick-borne encephalitis, and Ebola virus infection.


Cat. No.: EX-A13355	Purity: >98%

	Chemical structure of Virapinib

For research only, Do not use for Human!

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CAS No.	1794091-10-3
Purity	>98%
Formula	C26H36N6O
Mol Weight	448.6036
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Porebski B, et al. Discovery of a novel inhibitor of macropinocytosis with antiviral activity. Mol Ther. 2024;32(9):3012-3024. [2]. Barz, Myriam. Chemical and genetic screening approaches for the discovery of novel treatments. Karolinska Institutet. Thesis. (2025) [3]. Wanda Christ, et al. HANTAVIRUSES AND SARS-COV-2: CELL STRESS AND NOVEL ANTIVIRALS.
CoA	CoA of Virapinib

Smiles:	CC(CC1)CCN1C2=CC=C(C(N3CCC(C4=NC5=C(CCN(C)C5)C(NC)=N4)C3)=O)C=C2


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