VHL Ligand-Linker Conjugates 7

(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .


Cat. No.: EX-A8732A	Purity: >98%

	Chemical structure of VHL Ligand-Linker Conjugates 7

For research only, Do not use for Human!

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Synonyms	E3 ligase Ligand-Linker Conjugates 10
Synonyms 2	VH032-PEG2-C4-Cl
CAS No.	1835705-57-1
Purity	>98%
Formula	C32H47ClN4O6S
Mol Weight	651.257
Color	Light yellow to yellow
State	solid powder
Solubility	H2O: 50 mg/mL DMSO ? 50 mg/mL Ethanol: 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Craig Crews, et al. Proteolysis Targeting Chimera Compounds and Methods of Preparing and Using Same. US20170121321A1. [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.
CoA	CoA of VHL Ligand-Linker Conjugates 7

Smiles:	O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2


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