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Product Information:

VHL Ligand-Linker Conjugates 10

(S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

Cat. No.: EX-A8732C    Purity: >98%
Chemical
Chemical structure of VHL Ligand-Linker Conjugates 10


For research only, Do not use for Human!

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SynonymsE3 ligase Ligand-Linker Conjugates 9
Synonyms 2VH032-PEG6-C4-Cl
CAS No.1835705-59-3
Purity>98%
FormulaC40H63ClN4O10S
Mol Weight827.467
ColorLight yellow to yellow
Statesolid powder
SolubilityEthanol: 100 mg/mL DMSO? 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder   -20°C, 3 years , 4°C, 2 years ; In solvent   -20°C, 1 month
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Tovell H, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019 May 17;14(5):882-892.

CoACoA of VHL Ligand-Linker Conjugates 10
Smiles:O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

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