VH-N412

VH-N412 is a vectorized neuropeptide (NT) with good blood-brain barrier permeability. VH-N412 binds to the low-density lipoprotein receptor (LDLR) and neuropeptide receptor 1 (NTSR-1), and acts as a pharmacological-induced hypothermia (PIH) inducer. VH-N412 exhibits anticonvulsant and neuroprotective effects, and can be used in the study of neurological diseases such as epilepsy.


Cat. No.: EX-A13037	Purity: >98%

	Chemical structure of VH-N412

For research only, Do not use for Human!

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CAS No.	1801681-81-1
Purity	>98%
Formula	C94H163N27O24S3
Mol Weight	2151.662
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ferhat L, et al. A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice[J]. bioRxiv, 2024: 2024.07. 15.603208.
CoA	CoA of VH-N412

Smiles:	C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)[C@H](CC)C)=O)(=O)[C@H]2N(C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCNC(=O)[C@@H]3CSSC[C@@H](NC(CC)=O)C(=O)N[C@@H](CCSC)C(=O)N4[C@](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC


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