Verteporfin

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis^[1]. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation^[3].


Cat. No.: EX-A1344	Purity: >98%

	Chemical structure of Verteporfin

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	598	In-stock
250mg	898	In-stock
500mg	1385	In-stock
1g	1885	In-stock

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CAS No.	129497-78-5
Purity	>98%
Formula	C41H42N4O8
Mol Weight	718.7942
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Morishita T, et al. The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with BMS-354825. Oncotarget. 2016 Aug 2. [2]. Pan W, et al. Verteporfin can Reverse the NSC 125973 Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. Cell Physiol Biochem. 2016;39(2):481-90. [3]. Donohue E, et al. The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.J Cancer. 2013 Aug 28;4(7):585-96.
CoA	CoA of Verteporfin

Smiles:	COC(=O)CCC1=C2NC(\C=C3/N=C(/C=C4NC(=C\C5=N\C(=C/2)\C(CCC(O)=O)=C5C)/C(C=C)=C\4C)C2=CC=C([C@@H](C(=O)OC)[C@@]32C)C(=O)OC)=C1C


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