Verlukast sodium

MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release.


Cat. No.: EX-A2327	Purity: >98%

	Chemical structure of Verlukast sodium

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	485	In-stock
250mg	725	In-stock
500mg	950	In-stock
1g	1185	In-stock
5g	3385	In-stock

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Synonyms	MK-571 sodium
Synonyms 2	L-660711
CAS No.	115103-85-0
Purity	>98%
Formula	C26H26ClN2NaO3S2
Mol Weight	537.069
State	solid powder
Solubility	Soluble in H2O, DMSO : < 1 mg/mL (insoluble or slightly soluble)
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jones TR, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28. [2]. Hara Y, et al. Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. J Clin Invest. 2011 Jul;121(7):2888-97. [3]. Mitra P, et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16394-9.
CoA	CoA of Verlukast sodium

Smiles:	[Na+].CN(C)C(=O)CCSC(SCCC([O-])=O)C1=CC=CC(\C=C\C2=NC3=CC(Cl)=CC=C3C=C2)=C1


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