VEGFR2-IN-84

VEGFR2-IN-84 is an orally active, multi-targeted tyrosine kinase inhibitor based on a naphthalene ring scaffold. VEGFR2-IN-84 inhibits VEGFR2 with sub-nanomolar affinity and broadly targets kinases including Kit, FGFR, PDGFR, and Ret. By competitively binding to the ATP-binding pocket, VEGFR2-IN-84 blocks the phosphorylation of VEGFR2 and its downstream AKT/ERK signaling pathway, thereby significantly inhibiting endothelial cell proliferation, migration, and tumor angiogenesis. VEGFR2-IN-84 exhibits broad-spectrum antiproliferative activity against various solid tumors such as liver cancer, lung cancer, and renal cancer, shows weak toxicity to normal cells, and has superior potency to Lenvatinib (HY-10981). VEGFR2-IN-84 possesses favorable pharmacokinetic properties and high safety (LD50>2000 mg/kg), and can be used in related studies of various malignant tumors .


Cat. No.: EX-A16765	Purity: >98%

	Chemical structure of VEGFR2-IN-84

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
25mg	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	861877-12-5
Purity	>98%
Formula	C25H18N4O4S
Mol Weight	470.5

Reference:	[1].Yang T, et al. Structure-Based Discovery of Novel, Highly Potent VEGFR2 Inhibitors with a Naphthalene Scaffold against a Broad Range of Solid Tumors. J Med Chem. Published online March 20, 2026.
CoA	CoA of VEGFR2-IN-84

Smiles:	NC(C1=C(C=C(C2=C1)N=CC=C2OC3=CC4=C(C=C3)C(C(NC5=NC=CS5)=O)=CC=C4)OC)=O


		Search