VAV1 degrader-2

VAV1 degrader-2 is a molecular glue degrader based on targeting Vav guanine nucleotide exchange factor 1 (VAV 1) with a DC50 of 4.41 nM. VAV1 degrader-2 can be used in the study of inflammatory and autoimmune diseases.


Cat. No.: EX-A12317	Purity: >98%

	Chemical structure of VAV1 degrader-2

For research only, Do not use for Human!

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CAS No.	3050683-29-6
Purity	>98%
Formula	C22H20ClN3O2
Mol Weight	393.866
Color	White to off-white
State	Solid
Solubility	DMSO : 20 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Laura Ann Mcallister, et al. Targeted degradation of vav1. WO2024151547A1. 2024-01-08
CoA	CoA of VAV1 degrader-2

Smiles:	O=C1NC(=O)C(C=2C=CC=C(C=3C=CC(=CC3)CC4=NN(C=C4)C)C2Cl)CC1


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