Valerenic acid

Valerenic acid, a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties.


Cat. No.: EX-A10774	Purity: >98%

	Chemical structure of Valerenic acid

For research only, Do not use for Human!

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Synonyms	(-)-Valerenic Acid
CAS No.	3569-10-6
Purity	>98%
Formula	C15H22O2
Mol Weight	234.334
Color	White to off-white
State	Solid
Solubility	Soluble in Ethanol
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, protect from light; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Benke D, et, al. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2009 Jan;56(1):174-81. [2]. Dietz BM, et, al. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res Mol Brain Res. 2005 Aug 18;138(2):191-7. [3]. Kara M, et, al. Ameliorative Effects of the Sesquiterpenoid Valerenic Acid on Oxidative Stress Induced in HepG2 Cells after Exposure to the Fungicide Benomyl. Antioxidants (Basel). 2021 May 8;10(5):746. [4]. Becker A, et, al. The anxiolytic effects of a Valerian extract is based on valerenic acid. BMC Complement Altern Med. 2014 Jul 28;14:267.
CoA	CoA of Valerenic acid

Smiles:	O=C(O)/C(C)=C/[C@H]1C2=C(C)CC[C@]2([H])[C@H](C)CC1


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