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Product Information:

URMC-099

URMC-099 is an orally bioavailable and potent mixed lineage kinase type 3 (MLK3) (IC50=14 nM) inhibitor.

Cat. No.: EX-A1276    Purity: >98%
Chemical
Chemical structure of URMC-099


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg645In-stock
1g972In-stock
5g3256In-stock
10g4985In-stock


CAS No.1229582-33-5
Purity>98%
FormulaC27H27N5
Mol Weight421.5368
Statesolid powder
SolubilityDMSO > 30mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Goodfellow VS, et al. Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48.

[2]. Rhoo KH, et al. Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model. PLoS One. 2014 Sep 29;9(9):e108487.

CoACoA of URMC-099
Smiles:CN1CCN(CC2=CC=C(C=C2)C2=CN=C3NC=C(C3=C2)C2=CC3=C(NC=C3)C=C2)CC1

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