UNC9426

UNC9426 is a potent and selective TYRO3 inhibitor (IC50 = 2.1 nM), demonstrating 276-fold and 90-fold selectivity over MERTK and AXL, respectively. UNC9426 reduces platelet aggregation without increasing bleeding time and blocks TYRO3-dependent functions in tumor cells and macrophages. UNC9426 demonstrates a favorable safety profile with no significant increase in bleeding risk in vivo. UNC9426 can be used for functional studies of TYRO3-dependent phenotypes such as non-small cell lung cancer (NSCLC).


Cat. No.: EX-A14019	Purity: >98%

	Chemical structure of UNC9426

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	580	In-stock
250mg	1080	In-stock
500mg	1680	In-stock
1g	2480	In-stock

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CAS No.	3051784-94-9
Purity	>98%
Formula	C32H34F6N6O
Mol Weight	632.6424
Color	White to off-white
State	Solid
Solubility	DMSO : 20.59 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kong D, et al. UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor. J Med Chem. 2025 Mar 27;68(6):6665-6682
CoA	CoA of UNC9426

Smiles:	O[C@H](CC1)CC[C@@H]1N2C=C(C3=CC=C(C=C3)CN4CCN(CC4)C)C5=CN=C(N=C52)NC6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6


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