UNC6852

UNC6852 is a selective degrader that targets polycomb repressive complex 2 (PRC2). UNC6852 is based on PROTAC and contains an EED226-derived ligand and a ligand for VHL with IC50 of 247 nM for EED.


Cat. No.: EX-A3973	Purity: >98%

	Chemical structure of UNC6852

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	475	In-stock
25mg	650	In-stock
50mg	950	In-stock
100mg	1250	In-stock
200mg	1785	In-stock

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CAS No.	2688842-08-0
Purity	>98%
Formula	C43H48N10O6S
Mol Weight	832.97
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.
CoA	CoA of UNC6852

Smiles:	O=C(C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4)NCCCC(N[C@H](C(N5[C@@H](C[C@H](C5)O)C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)=O)C(C)(C)C)=O


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