UNC5293

UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research.


Cat. No.: EX-A5244	Purity: >98%

	Chemical structure of UNC5293

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	3200	Inquire
200mg	4800	In-stock
500mg	get quote	In-stock

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CAS No.	2226789-82-6
Purity	>98%
Formula	C30H42N6O2
Mol Weight	518.6935
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hongchao Zheng, et al. UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem. 2021 May 17;220:113534.
CoA	CoA of UNC5293

Smiles:	O=C(C1=CC(C)=NC(C)=C1)N2CCC(C3=CN([C@H]4CC[C@H](O)CC4)C5=NC(N[C@@H](C)CCC)=NC=C53)CC2


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