UNC0638

UNC0638 selectively inhibits G9a and GLP histone methyltransferase activity with IC50s of less than 15 nM and 19 nM, respectively. UNC0638 has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities.


Cat. No.: EX-A2205	Purity: >98%

	Chemical structure of UNC0638

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	800	In-stock
500mg	1085	In-stock
1g	1450	In-stock
5g	4685	In-stock
10g	7496	In-stock

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CAS No.	1255580-76-7
Purity	>98%
Formula	C30H47N5O2
Mol Weight	509.7265
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Vedadi M, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74. [2]. Fu L, et al. Effects of the Histone Methyltransferase Inhibitor UNC0638 on Histone H3K9 Dimethylation of Cultured Ovine Somatic Cells and Development of Resulting Early Cloned Embryos. Reprod Domest Anim. 2014 Apr;49(2):e21-5. [3]. Singh N, et al. Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. J Interferon Cytokine Res. 2016 Jan;36(1):37-47.
CoA	CoA of UNC0638

Smiles:	COC1=CC2=C(NC3CCN(CC3)C(C)C)N=C(N=C2C=C1OCCCN1CCCC1)C1CCCCC1


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