UNC-2170

UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1].


Cat. No.: EX-A15183	Purity: >98%

	Chemical structure of UNC-2170

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	680	In-stock
1g	990	In-stock
2g	1850	In-stock

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CAS No.	1648707-58-7
Purity	>98%
Formula	C14H21BrN2O
Mol Weight	313.233
Color	Colorless to light yellow
State	viscous liquid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent-20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Perfetti MT, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol. 2015;10(4):1072-1081.
CoA	CoA of UNC-2170

Smiles:	O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1


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