UCB1244283

UCB1244283 is a synaptic vesicle glycoprotein 2A (SV2A) allosteric modulator. UCB1244283 binds to a secondary ligand-binding site in SV2A and enhances orthosteric ligand engagement when the orthosteric site is occupied, by stabilizing the occluded state and slowing ligand dissociation. UCB1244283 shows a clear protective effect against both tonic and clonic convulsions in sound-sensitive mice. UCB1244283 can be used for epilepsy research.


Cat. No.: EX-A17023	Purity: >98%

	Chemical structure of UCB1244283

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	488	in-stock
100mg	695	in-stock
250mg	1172	in-stock
1g	2360	in-stock

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CAS No.	300587-89-7
Purity	>98%
Formula	C20H25NO2
Mol Weight	311.418
Color	White to off-white
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pidathala S, et al. Structural pharmacology of SV2A reveals an allosteric modulation mechanism in the major facilitator superfamily. Nat Commun. 2025 Nov 28;16(1):10748. [2]. Wood MD, et al. Further evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A protein. Epilepsia. 2018 Sep;59(9):e147-e151. [3]. Daniels V, et al. Modulation of the conformational state of the SV2A protein by an allosteric mechanism as evidenced by ligand binding assays. Br J Pharmacol. 2013 Jul;169(5):1091-101.
CoA	CoA of UCB1244283

Smiles:	O=C(NC1=CC=CC=C1OC)CC(C)CC2=CC(C)=CC(C)=C2


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