(±)-U-50488 hydrate hydrochloride

(-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (b>Kd=2.2 nM) over μ-opioid receptor (MOR) (b>Kd=430 nM). (-)-U-50488 hydrochloride is a more active enantiomer than (+) trans-(1R,2R) U-50488 or the (±) trans-racemic mixture U-50488 . (-)-U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM)[1].


Cat. No.: EX-A15230	Purity: >98%

	Chemical structure of (±)-U-50488 hydrate hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	495	In-stock
50mg	780	In-stock
100mg	1240	In-stock
250mg	2400	In-stock
500mg	4050	In-stock
1g	6300	In-stock

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Synonyms	(-)-Trans-(1S,2S)-U-50488 hydrochloride
CAS No.	114528-79-9
Purity	>98%
Formula	C19H27Cl3N2O
Mol Weight	405.789
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kirti Kumari Sharma, et al. The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning. Forensic Toxicol. 2019;37(1):1-16. [2]. Anthony S Zannas, ET AL. Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice. Psychopharmacology (Berl). 2017 Mar;234(6):913-923. [3]. C C Chao,et al. U50488 inhibits HIV-1 expression in acutely infected monocyte-derived macrophages. Drug Alcohol Depend. 2001 Apr 1;62(2):149-54.
CoA	CoA of (±)-U-50488 hydrate hydrochloride

Smiles:	CN([C@H]1CCCC[C@@H]1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl


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