Type II TRK inhibitor 2

Type II TRK inhibitor 2 (compound 40l) is a selective type II TRK inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKA ^G595R and Ba/F3-TRKA ^G667C cell proliferation (IC50: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers .


Cat. No.: EX-A8681	Purity: >98%

	Chemical structure of Type II TRK inhibitor 2

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	1285	Inquire
50mg	1485	Inquire
100mg	1685	Inquire
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Purity	>98%
Formula	C30H27F2N9O
Mol Weight	567.5919

Reference:	[1]. Qin Q et al. Discovery of novel 3-(1H-pyrazol-4-yl)-1H-indazole derivatives as potent type II TRK inhibitors against acquired resistance[J]. European Journal of Medicinal Chemistry, 2023: 115953.
CoA	CoA of Type II TRK inhibitor 2

Smiles:	O=C(NC1=CC(C(C)(C)C)=NN1C2=CC(F)=CC(F)=C2)NC3=CC=CC(NC4=CC5=C(C=C4)C(C6=CNN=C6)=NN5)=C3


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