Type II topoisomerase inhibitor 1

Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC50: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC50: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area.


Cat. No.: EX-A8787	Purity: >98%

	Chemical structure of Type II topoisomerase inhibitor 1

For research only, Do not use for Human!

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CAS No.	2245691-60-3
Purity	>98%
Formula	C18H15N3O4
Mol Weight	337.3294

Reference:	[1]. Fumihito Ushiyama, et al. Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation. ACS Omega. 2020 Apr 24;5(17):10145-10159. [2]. Fumihito Ushiyama, et al. Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115776.
CoA	CoA of Type II topoisomerase inhibitor 1


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