Tyk2-IN-20

Tyk2-IN-20 (Example 289) is a potent Tyk2 inhibitor with an IC50 of <5 nM. Tyk2-IN-20 als inhibits JAK1, JAK2, and JAK3 with IIC50 values of <100 nM. Tyk2-IN-20 can be used for the study of inflammatory diseases.


Cat. No.: EX-A12790	Purity: >98%

	Chemical structure of Tyk2-IN-20

For research only, Do not use for Human!

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CAS No.	3058568-08-1
Purity	>98%
Formula	C24H25N7O2
Mol Weight	443.501
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nathan Edward GENUNG, et al. 1h-pyrrolo[2,3-b]pyridin-4-yl]-2-oxopyrrolidine-3-carbonitrile derivatives as tyrosine kinase 2 (tyk2) inhibitors for the treatment of inflammatory diseases. WO2024211696A1.
CoA	CoA of Tyk2-IN-20

Smiles:	C[C@@H]([C@@](C#N)(C1CC1)C2=O)CN2C3=NC(C4=CN(C5CC6(COC6)C5)N=C4)=CN7C3=CC=N7


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