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Product Information:

TWIK-1/TREK-1-IN-3

TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TWIK-1/TREK-1-IN-3 has antidepressant-like effects.

Cat. No.: EX-A8071    Purity: >98%
Chemical
Chemical structure of TWIK-1/TREK-1-IN-3


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg1000In-stock
500mg1600In-stock
1g2400In-stock


CAS No.1440532-33-1
Purity>98%
FormulaC19H27F3N2O2
Mol Weight372.4251
ColorWhite to off-white
Statesolid powder
SolubilityDMSO : 25 mg/mL 
Shelf Life>3 years if stored properly
StoragePowder   -20°C, 3 years , 4°C, 2 years ; In solvent    -20°C, 1 month
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. .

CoACoA of TWIK-1/TREK-1-IN-3
Smiles:O[C@H](COC1=CC=C(C(F)(F)F)C=C1)CN2CCC(N3CCCC3)CC2

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