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Product Information:

Tucatinib

Tucatinib (Irbinitinib) is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.

Cat. No.: EX-A1031    Purity: >99%
Chemical
Chemical structure of Tucatinib


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg250In-stock
1g350In-stock
5g900In-stock
10g1550In-stock
25g2550In-stock
50g3950In-stock


SynonymsIrbinitinib
Synonyms 2ARRY-380
CAS No.937263-43-9
Purity>99%
FormulaC26H24N8O2
Mol Weight480.5212
Coloroff-white
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Moulder-Thompson S, et al. Phase 1 Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+ Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC). Clin Cancer Res. 2017 Jan 4. pii: clincanres.1496.2016.

[2]. Abstract: In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 852. doi:1538-7445.AM2012-852

[3]. P. Lee, et al. In Vivo Activity of ARRY-380, a Potent, Small Molecule Inhibitor of ErbB2 in Combination with RP-56976. Cancer Research

CoACoA of Tucatinib
Smiles:CC1=C(OC2=CC3=NC=NN3C=C2)C=CC(NC2=NC=NC3=C2C=C(NC2=NC(C)(C)CO2)C=C3)=C1

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