Tubulin polymerization-IN-79

Tubulin polymerization-IN-79 (Compound C20) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-79 shows potent antiproliferative activity against esophageal cancer cells (e.g., KYSE450, IC50=0.36 μM; EC-109, IC50=0.63 μM). Tubulin polymerization-IN-79 occupies the colchicine binding site to disrupt microtubule network integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP expression, and inducing G2/M phase arrest and apoptosis in esophageal cancer cells. Tubulin polymerization-IN-79 is promising for research of esophageal cancers .


Cat. No.: EX-A16336	Purity: >98%

	Chemical structure of Tubulin polymerization-IN-79

For research only, Do not use for Human!

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CAS No.	3095945-40-4
Purity	>98%
Formula	C19H15NO6S
Mol Weight	385.391
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Zhao D, et al. Discovery of novel coumarin-sulfonates as tubulin polymerization inhibitors targeting the colchicine-binding site with potent anticancer activities. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130284.
CoA	CoA of Tubulin polymerization-IN-79

Smiles:	O=C1OC=2C=CC=CC2C(OS(=O)(=O)C3=CC=C(C=C3)N4C(=O)CCC4)=C1


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