TRO40303

TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM).


Cat. No.: EX-A3773	Purity: >98%

	Chemical structure of TRO40303

For research only, Do not use for Human!

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Synonyms	TRO 40303
CAS No.	949080-24-4
Purity	>98%
Formula	C26H47NO2
Mol Weight	405.6569
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Schaller, Sophie et al. “TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition.” The Journal of pharmacology and experimental therapeutics vol. 333,3 (2010): 696-706. [2]. Le Lamer, Sophie et al. “Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial.” Journal of translational medicine vol. 12 38. 7 Feb. 2014 [3]. Hansson, Magnus J et al. “Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia/reperfusion injury.” European journal of pharmacology vol. 760 (2015): 7-19.
CoA	CoA of TRO40303

Smiles:	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC/C(=N\O)/[C@]3(C)CCCO)C


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