Tri-GalNAc(OAc)3 TFA

Tri-GalNAc(OAc)3 TFA is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3 TFA can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models.


Cat. No.: EX-A7801G	Purity: >98%

	Chemical structure of Tri-GalNAc(OAc)3 TFA

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	752	In-stock
1g	1256	In-stock
5g	3768	In-stock
10g	get quote	In-stock
25g	get quote	In-stock
100g	get quote	Inquire

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CAS No.	1159408-65-7
Purity	>98%
Formula	C81H129F3N10O38
Mol Weight	1907.9304
Color	white to off-white
State	solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ahn G, et al. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. Nat Chem Biol. 2021 Sep;17(9):937-946.
CoA	CoA of Tri-GalNAc(OAc)3 TFA


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