TREM2 agonist-2

VG-3927 (SAR448851) is a highly potent, selective, and orally bioavailable small-molecule TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) agonist. It functions via a novel molecular glue-like mechanism, binding directly to the transmembrane/ectodomain hydrophobic pocket of the TREM2 receptor. This interaction promotes the clustering and stable complex formation between TREM2 and its essential co-receptor DAP12, avoiding sequestration by soluble TREM2 (sTREM2) which frequently limits monoclonal antibody therapeutics.


Cat. No.: EX-A16970	Purity: >98%

	Chemical structure of TREM2 agonist-2

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	530	in_stock
10mg	850	in_stock
25mg	1229	in_stock
50mg	1660	in_stock
100mg	2175	in_stock
250mg	3921	in_stock

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Synonyms	VG-3927
CAS No.	2738485-98-6
Purity	>98%
Formula	C24H23ClFN5O
Mol Weight	451.924
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yuan S,et al. Discovery of a Small Molecule TREM2 Agonist with Improved In Vitro Pharmacokinetic Profile and Validated Target Engagement. ACS Med Chem Lett. 2025 Jul 29;16(8):1634-1640. [2]. Mirescu C. Characterization of the first TREM2 small molecule agonist, VG‐3927, for clinical development in Alzheimer’s disease. Alzheimers Dement. 2025 Jan 9;20(Suppl 6):e084622. doi: 10.1002/alz.084622. PMCID: PMC11712879. [3]. Yuan, Shaoren et al. “Discovery of an Achiral Small Molecule TREM2 Agonist with Improved Pharmacokinetic Profile and Validated Target Engagement.” bioRxiv : the preprint server for biology 2025.06.22.660908. 26 Jun. 2025, doi:10.1101/2025.06.22.660908. Preprint.
CoA	CoA of TREM2 agonist-2

Smiles:	CC1=NC=2C(=NC(=CC2N=C1C)[C@@H]3C[C@@H](OCC3)C4=CN(C)N=C4)C5=C(F)C=C(Cl)C=C5


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