Tracazolate hydrochloride

Tracazolate (ICI 136753) hydrochloride is a potent GABAA receptor modulator. Tracazolate hydrochloride has selectivity for β3 and potentiates α1β1γ2s (EC50=13.2 μM), α1β3γ2 (EC50=1.5 μM). Tracazolate hydrochloride has the potency (EC50) determined by the nature of the third subunit (γ1-3, δ, ε) within the receptor complex. Tracazolate hydrochloride possesses anxiolytic and anticonvulsant activity


Cat. No.: EX-A6821	Purity: >98%

	Chemical structure of Tracazolate hydrochloride

For research only, Do not use for Human!

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CAS No.	1135210-68-2
Purity	>98%
Formula	C16H25ClN4O2
Mol Weight	340.848
Color	Off-white to light yellow
State	solid powder
Solubility	Soluble in DMSO 125 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sally-Anne Thompson, et al. Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors. Mol Pharmacol. 2002 Apr;61(4):861-9. [2]. N Zheleznova, et al. alpha1beta2delta, a silent GABA_A receptor: recruitment by tracazolate and neurosteroids. Br J Pharmacol. 2008 Mar;153(5):1062-71.
CoA	CoA of Tracazolate hydrochloride


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