TPX-0131

TPX-0131 is a CNS-penetrant, next-generation ALK inhibitor that has potency against wild-type ALK and a spectrum of acquired resistance mutations. >98% by HPLC;


Cat. No.: EX-A5132	Purity: >98%

	Chemical structure of TPX-0131

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	900	In-stock
250mg	1450	In-stock
500mg	2050	In-stock
1g	3200	In-stock
5g	get quote	In-stock
10g	get quote	In-stock

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Synonyms	Zotizalkib
Synonyms 2	TPX0131
CAS No.	2648641-36-3
Purity	>98%
Formula	C21H20F3N5O3
Mol Weight	447.4104
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 25 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Murray BW, Zhai D, Deng W, Zhang X, Ung J, Nguyen V, Zhang H, Barrera M, Parra A, Cowell J, Lee DJ, Aloysius H, Rogers E. TPX-0131, a Potent CNS-Penetrant, Next-Generation Inhibitor of Wild-Type ALK and ALK-Resistant Mutations. Mol Cancer Ther. 2021 Jun 22:molcanther.0221.2021. doi: 10.1158/1535-7163.MCT-21-0221. Epub ahead of print. PMID: 34158340.
CoA	CoA of TPX-0131

Smiles:	FC(F)[C@@H]1COC(C(N1CC2=C(OCC(C)(C)NC3=O)C=CC(F)=C2)=N4)=CN5C4=C3C=N5


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