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Product Information:

TPX-0046

TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay.

Cat. No.: EX-A5454A    Purity: >98%
Chemical
Chemical structure of TPX-0046


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mg500In-stock
25mg750In-stock
50mg1050In-stock
100mg1450In-stock
200mg1950In-stock
500mg3000In-stock


SynonymsTPX0046
CAS No.2359650-19-2
Purity>98%
FormulaC21H21FN6O3
Mol Weight424.4282
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO 5 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Alexander E Drilon, et al. The next-generation RET inhibitor TPX-0046 is active in drug-resistant and naïve RET-driven cancer models. Journal of Clinical. 2020 May; 38(15_suppl): 3616.

[2]. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.

[3]. Choudhury, N. J., & Drilon, A. (2020). Decade in review: a new era for RET-rearranged lung cancers. Translational lung cancer research, 9(6), 2571–2580.

CoACoA of TPX-0046

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