TPN171

TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH).


Cat. No.: EX-A6740	Purity: >98%

	Chemical structure of TPN171

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	650	In-stock
100mg	850	In-stock
250mg	1300	In-stock
500mg	1850	In-stock
1g	2850	In-stock
5g	get quote	In-stock

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Synonyms	Simenafil
Synonyms 2	TPN-171
CAS No.	1229018-87-4
Purity	>98%
Formula	C24H35N5O3
Mol Weight	441.5664
Color	White to off-white
State	solid
Solubility	Soluble in DMSO 25 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990.
CoA	CoA of TPN171


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