TPMPA

TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3].


Cat. No.: EX-A14609	Purity: >98%

	Chemical structure of TPMPA

For research only, Do not use for Human!

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CAS No.	182485-36-5
Purity	>98%
Formula	C6H12NO2P
Mol Weight	161.1387
Color	White to off-white
State	Solid
Solubility	soluble in H2O
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, protect from light, stored under nitrogen; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Martínez-Torres A, et al. GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization. Proc Natl Acad Sci U S A. 2000;97(7):3562-3566. [2]. Graham A. R. Johnston, et al. Neurologically-active compounds. WO1998058939A1 [3]. Johnston GA. GABAc receptors: relatively simple transmitter -gated ion channels?. Trends Pharmacol Sci. 1996;17(9):319-323.
CoA	CoA of TPMPA

Smiles:	CP(=O)(C1=CCNCC1)O


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