TP0628103

TP0628103 is a potent and highly selective MMP-7 inhibitor with an IC50 of 0.17 nM. TP0628103 undergoes structural optimization via molecular isoelectric point shifting, which reduces organic anion transporter (OAT)-mediated clearance, while maintaining potent MMP-7 inhibitory activity and enhancing MMP subtype selectivity. TP0628103 is applicable for research on the regulatory mechanisms of MMP-7-related matrix metalloproteinases .


Cat. No.: EX-A9830	Purity: >98%

	Chemical structure of TP0628103

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	get quote	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2865102-08-3
Purity	>98%
Formula	C51H67ClF3N11O11S
Mol Weight	1134.658
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Oka Y, et al. Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points. Journal of medicinal chemistry. 2024 Jan 25;67(2):1406-1420.
CoA	CoA of TP0628103

Smiles:	S(N[C@@H](CCC(NCC(N[C@@H](CC=1C=CN=CC1)C(N[C@H](C(NC2=CC=C(C(=O)N3CCC(C(N[C@@H](C(=O)N4CC[C@H](N)C4)CCCCN)=O)CC3)C=C2)=O)[C@@](C)(C)C)=O)=O)=O)C(O)=O)(=O)(=O)C5=CC(C(F)(F)F)=C(Cl)C=C5


		Search