TP0427736 hydrochloride

TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA).


Cat. No.: EX-A6696	Purity: >98%

	Chemical structure of TP0427736 hydrochloride

For research only, Do not use for Human!

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250mg	1550	Inquire
1g	2950	Inquire

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CAS No.	2459963-17-6
Purity	>98%
Formula	C14H11ClN4S2
Mol Weight	334.847
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in H2O 3.33 mg/mL DMSO 2 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Takumi Naruse, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 May;69(3):485-491.
CoA	CoA of TP0427736 hydrochloride


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