Tomaymycin DM

Tomaymycin DM is a derivative of Tomaymycin that belongs to the class of DNA alkylation inhibitors and acts as an effective payload for ADCs. Tomaymycin stabilizes the double-stranded DNA structure, inhibits various DNA processing enzymes, blocks transcription, and ultimately induces DNA strand breaks and apoptosis. Tomaymycin DM can be used in studies related to the development of ADCs targeting multiple cancers including leukemia and ovarian cancer.


Cat. No.: EX-A11815	Purity: >98%

	Chemical structure of Tomaymycin DM

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	1150	In-stock
100mg	1850	In-stock
250mg	3250	In-stock

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Synonyms	Pyrrolobenzodiazepine
Synonyms 2	PBD
CAS No.	945490-09-5
Purity	>98%
Formula	C14H14N2O3
Mol Weight	258.2726
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, stored under nitrogen; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Foloppe MP, Rault S, Thurston DE, Jenkins TC, Robba M. DNA-binding properties of pyrrolo [2, 1-c][1, 4] benzodiazepine N10-C11 amidines. European journal of medicinal chemistry. 1996 Jan 1;31(5):407-10. [2]. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017;56(2):462-488.
CoA	CoA of Tomaymycin DM

Smiles:	COC1=C(C=C2C(=C1)C(=O)N3CC(=C)C[C@H]3C=N2)O


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