Tolebrutinib

Tolebrutinib (SAR442168) is a potent, selective and brain-penetrant BTK inhibitor, with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.


Cat. No.: EX-A4699	Purity: >98%

	Chemical structure of Tolebrutinib

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	513	in_stock
500mg	822	in_stock
1g	1311	in_stock

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Synonyms	SAR442168
Synonyms 2	PRN2246
CAS No.	1971920-73-6
Purity	>98%
Formula	C26H25N5O3
Mol Weight	455.5084
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Dahl K, et, al. Radiosynthesis of a Bruton's tyrosine kinase inhibitor, [ 11 C]Tolebrutinib, via palladium-NiXantphos-mediated carbonylation. J Labelled Comp Radiopharm. 2020 Sep;63(11):482-487. [2]. Francesco MR, et, al. PRN2246, a potent and selective blood brain barrier penetrating BTK inhibitor, exhibits efficacy in central nervous system immunity. Multiple Sclerosis Journal. 2017;Poster Session 2:P989.
CoA	CoA of Tolebrutinib

Smiles:	C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=NC=C3)N)N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5


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