TNO155

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors.


Cat. No.: EX-A3645	Purity: >98%

	Chemical structure of TNO155

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	750	In-stock
500mg	1150	In-stock
1g	1750	In-stock
2g	2950	In-stock
5g	5975	In-stock
10g	8250	In-stock

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Synonyms	Batoprotafib
CAS No.	1801765-04-7
Purity	>98%
Formula	C18H24ClN7OS
Mol Weight	421.947
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. I. Braña, C. Serrano. GIST DISEMINADO: NUEVOS ENSAYOS DEL GEIS. 2017 Nov 20th. [2]. Liu C, et al. Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling. Clin Cancer Res. 2021 Jan 1;27(1):342-354. [3]. Weiss A, et al. Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C. Cancer Discov. 2022 Jun 2;12(6):1500-1517.
CoA	CoA of TNO155

Smiles:	N[C@@H]1[C@H](C)OCC12CCN(C3=NC(N)=C(SC4=C(Cl)C(N)=NC=C4)N=C3)CC2


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