TMX1

TMX1 is a covalent, selective BRD4 molecular glue degrader. TMX1 binds to the JQ1-binding site of BRD4BD2, forms covalent bonds with Cys58 of DCAF16 and Cys87 of GAK in a BRD4BD2-dependent template-assisted manner, stabilizes the BRD4-TMX1-DCAF16 ternary complex, and promotes the ubiquitination of BRD4 via the CRL4DCAF16 ubiquitin ligase complex. TMX1 induces selective degradation of BRD4, mild degradation of BRD2 and BRD3, as well as DCAF16-dependent cytotoxicity.


Cat. No.: EX-A11426	Purity: >98%

	Chemical structure of TMX1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	1180	Inquire
100mg	1880	Inquire
250mg	3580	Inquire
500mg	5680	Inquire

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CAS No.	3079093-92-5
Purity	>98%
Formula	C26H28N4O3S
Mol Weight	476.591
Color	White to off-white
State	Solid
Solubility	DMSO : ? 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Li YD, et al. Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528208. [2]. Li YD, et al. Template-assisted covalent modification underlies activity of covalent molecular glues. Nat Chem Biol. 2024;20(12):1640-1649.
CoA	CoA of TMX1

Smiles:	CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)/C=C/C=O)C


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