TMU 35435

TMU 35435 is a histone deacetylase (HDAC) inhibitor. TMU-35435 inhibits the NHEJ pathway through ubiquitination of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In addition, TMU 35435 enhances radiosensitivity by inducing misfolded protein aggregation and autophagy in TNBC.


Cat. No.: EX-A13214	Purity: >98%

	Chemical structure of TMU 35435

For research only, Do not use for Human!

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CAS No.	2231800-32-9
Purity	>98%
Formula	C22H25N3O3
Mol Weight	379.4522
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Huiwen Chiu, et al. "A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer." Cancers 11.11 (2019): 1703. [2]. Yuanhua Wu, et al. "A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer." Cancer letters 400 (2017): 79-88.
CoA	CoA of TMU 35435

Smiles:	O=C(NCCCCCCC(=O)NO)C1=CC=CC=2C=C3C=CC=C(C3=NC21)C


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