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Product Information:

TLR8 antagonist-1

TLR8 antagonist-1 (Compound 10) is a selective TLR8 antagonist. TLR8 antagonist-1 can inhibit TLR8-mediated inflammation and signaling pathways, reduce the recruitment of MyD88, and inhibit the NF-κB and IRF pathways. TLR8 antagonist-1 has anti-inflammatory activity .

Cat. No.: EX-A15830    Purity: >98%
Chemical
Chemical structure of TLR8 antagonist-1


For research only, Do not use for Human!

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CAS No.1111460-83-3
Purity>98%
FormulaC21H29N3O4
Mol Weight387.4727
ColorWhite to off-white
StateSolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Matziol T, et al. Discovery of Novel Isoxazole-Based Small-Molecule Toll-Like Receptor 8 Antagonists. J Med Chem. 2025 Feb 27;68(4):4888-4907.

CoACoA of TLR8 antagonist-1
Smiles:CC1=NOC(C)=C1COC2=C(OC)C=C(C(NC3CCN(CC)CC3)=O)C=C2

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